About ROMA® and HE4

About HE4

Take the right treatment path.

Contact a distributor to
order the HE4 test.

What is HE4?

HE4 (Human Epididymal Secretory Protein 4) is a 20-25 kDa secretory protein and consists of an approximate 13kDa protein core. The epididymal secretory protein E4 is overexpressed in ovarian carcinoma. Normal ovarian tissue has minimal gene expression and production of HE4. Separately, an analysis of serum obtained from patients with benign ovarian tumors demonstrated that HE4 had a sensitivity of 67% and a specificity of 96%.7

In this study, various tumor markers were evaluated, and HE4 had the highest sensitivity as a single marker. When combined with CA125, the sensitivity increased to an even greater degree than either marker alone.7

HE4 Intended Use

The HE4 EIA is an enzyme immunometric assay for the quantitative determination of HE4 in human serum.

The assay is to be used as an aid in monitoring recurrence or progressive disease in patients with epithelial ovarian cancer. Serial testing for patient HE4 assay values should be used in conjunction with other clinical methods used for monitoring ovarian cancer.

Click here for full HE4 package insert.